Research progress on stem cells in the treatment of sepsis
10.12206/j.issn.2097-2024.202509039
- VernacularTitle:干细胞用于脓毒症治疗的研究进展
- Author:
Ting CHEN
1
;
Linlin CHEN
2
;
Zhao CHEN
2
;
Junping ZHANG
2
;
Yan WANG
3
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
2. School of Anesthesiology, 2b. School of Pharmacy, Naval Medical University, Shangha 200433, China.
3. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Anesthesiology, 2b. School of Pharmacy, Naval Medical University, Shangha 200433, China;Innovation Center for Medical Basic Research on Fungal Infectious Diseases, Ministry of Education, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
sepsis;
stem cells;
immune response;
inflammation
- From:
Journal of Pharmaceutical Practice and Service
2026;44(2):59-64
- CountryChina
- Language:Chinese
-
Abstract:
At present, the treatment of sepsis depends largely on non-specific methods, highlighting an urgent need for novel therapeutic strategies. Stem cells have garnered significant attention in the treatment of various diseases due to their unique biological properties. Stem cells enhance sepsis survival through mechanisms such as reducing bacterial burden, modulating inflammation, and ameliorating organ dysfunction. Recent studies have shown that stem cells can increase the survival rate of sepsis patients through multiple pathways such as reducing the bacterial load of the host, regulating inflammatory homeostasis, and improving multi-organ dysfunction. Their derivatives, exosomes, can also alleviate the imbalanced immune response in sepsis patients. Recent advances in stem cell-based therapies for sepsis were summarized in this paper.
