Helicobacter pylori infection affecting the risk of colorectal adenomatous polyps in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.01.027
- VernacularTitle:幽门螺杆菌感染影响2型糖尿病患者发生结直肠腺瘤性息肉风险的研究
- Author:
Lina CHEN
1
;
Zhengjuan LIU
2
;
Zhenli TANG
3
Author Information
1. Endoscopy Room, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, China
2. Department of Gastroenterology, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, China
3. Department of Endocrinology and Hematology, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Helicobacter pylori;
Colorectal adenomatous polyps;
Predictive value
- From:
Journal of Public Health and Preventive Medicine
2026;37(1):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of Helicobacter pylori (Hp) infection on the risk of colorectal adenomatous polyps in patients with type 2 diabetes mellitus (T2DM). Methods A total of 306 patients with T2DM who were treated in the hospital from April 2021 to April 2024 were enrolled as the study subjects. According to whether colorectal adenomatous polyps occurred, the enrolled patients were divided into adenomatous polyp group and non-adenomatous polyp group. The risk factors of colorectal adenomatous polyps in T2DM patients were discussed by univariate and Logistic multivariate regression analyses. The predictive value of Hp on the occurrence of colorectal adenomatous polyps was explored by receiver operating characteristic (ROC) curve. Results Among 306 T2DM patients, there were 142 cases of colorectal adenomatous polyps, with an incidence rate of 46.41%. After logistic analysis, it was found that Hp infection, concurrent gallbladder disease, fatty liver, alcohol drinking history and insulin use were independent influencing factors for colorectal adenomatous polyps (OR: 5.518, 95%CI: 2.806-10.850; OR: 2.782, 95%CI: 1.406-5.502; OR: 3.702, 95%CI: 1.684-8.141; OR: 2.125, 95%CI: 1.140-3.964; OR: 5.398, 95%CI: 2.528-11.525, P<0.05). ROR curve analysis indicated that the area under the curve (AUC), sensitivity and specificity of Hp infection in predicting colorectal adenomatous polyps were 0.611, 38.73% and 83.54%. Conclusion The occurrence of colorectal adenomatous polyps in patients with T2DM is affected by many factors among which Hp infection has obvious predictive value on its risk.
