Effect of bone metabolic markers on sarcopenia in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.01.026
- VernacularTitle:骨代谢标志物对老年2型糖尿病患者发生肌少症的影响
- Author:
Yamei WANG
1
;
Bin ZHONG
1
;
Xiaoqian CHEN
1
;
Haiyan SHANGGUAN
1
;
Jie LI
1
Author Information
1. Department of Endocrinology, Nanjing Central Hospital, Nanjing, Jiangsu 210018, China
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Type 2 diabetes mellitus;
Bone metabolic marker
- From:
Journal of Public Health and Preventive Medicine
2026;37(1):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bone metabolic markers on sarcopenia in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 412 patients with T2DM in the department of endocrinology of Nanjing Central Hospital from May 2020 to June 2025 were selected as the research subjects. According to Asian Working Group for Sarcopenia (AWGS) in 2019, these patients were evaluated for skeletal muscle mass index (ASMI), muscle strength, and muscle function, and were divided into a sarcopenia group (84 cases) and a non-sarcopenia group (328 cases). The glucolipid metabolic indexes were detected in both groups of patients, and the bone metabolic markers were evaluated, including procollagen type 1 N-terminal peptide (P1NP), beta-C-terminal telopeptide of type 1 collagen (β-CTX), and 25-hydroxy vitamin D [25-(OH)D]. The factors influencing the occurrence of sarcopenia in T2DM patients were analyzed by logistic regression analysis, and the diagnostic values of bone metabolic markers on sarcopenia in patients with T2DM were assessed by ROC curve. Results The levels of P1NP and 25-(OH)D were lower, while β-CTX level was higher in the sarcopenia group compared to the non-sarcopenia group, with statistical differences (P<0.05). After logistic correlation analysis, it was found that P1NP, β-CTX and 25-(OH)D were all influencing factors for the occurrence of sarcopenia in T2DM patients. ROC curve analysis suggested that combined detection of PINP, β-CTX, and 25-(OH)D had higher diagnostic value, with an area under the curve up to 0.805. Conclusion The abnormal expression of bone metabolic markers is associated with the increased risk of sarcopenia in patients with T2DM. The detection of serum bone metabolic markers expression level is of certain significance for the assessment of diabetes-related sarcopenia.
