Relationship between NLR and Hcy and the risk of coronary artery lesion progression in patients with hypertension
10.3969/j.issn.1006-2483.2026.01.025
- VernacularTitle:NLR、Hcy与高血压患者冠脉病变进展风险的关系研究
- Author:
Jibiao LIN
1
;
Ling YE
2
;
Ruiying LUO
1
;
Zirong FANG
2
Author Information
1. Cardiovascular Medicine, Ningde Normal University Affiliated Ningde City Hospital, Ningde , Fujian 352100, China
2. Department of Medical Imaging, Ningde Normal University Affiliated Ningde City Hospital, Ningde , Fujian 352100, China
- Publication Type:Journal Article
- Keywords:
Hypertension;
Progression of coronary artery lesion;
Neutrophil to lymphocyte ratio;
Homocysteine
- From:
Journal of Public Health and Preventive Medicine
2026;37(1):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of neutrophil to lymphocyte ratio (NLR) and homocysteine (Hcy) with risk of coronary artery lesion progression in patients with hypertension. Methods The data of 306 patients with hypertension who received coronary angiography from January 2020 to January 2025 were included for retrospective investigation. The patients were divided into a non-progression group (175 cases) and a progression group (131 cases) based on the 6-month Gensini progression rate. The relationship between NLR and Hcy and coronary artery lesion progression was analyzed. Results Binary logistic regression analysis was applied to control confounding factors. After adjusting for confounding factors using Model1, Model2, and Model3, it was found that NLR and Hcy at admission were independently associated with the progression of coronary artery lesion in hypertensive patients [adjusted OR (95% CI) = 1.77 (1.48-2.11), 4.26 (2.71-6.69), P<0.001]. Receiver operating characteristic (ROC) curve revealed that the area under the curve of the combination of Hcy and NLR was 0.814 in predicting the progression of coronary artery lesion in hypertensive patients, which was higher than that of Hcy or NLR (Z/P=5.328, 2.077/<0.05). Conclusion Cardiovascular disease risk factors NLR and Hcy are independently associated with coronary artery lesion progression in patients with hypertension. Early detection of NLR and Hcy is helpful to predict the progression of coronary artery lesion.
