Changes of levels of serum sST2 and ALB in patients with chronic heart failure and correlation with prognosis
10.3969/j.issn.1006-2483.2026.01.021
- VernacularTitle:慢性心力衰竭患者血清sST2、ALB水平变化及其与预后的相关性分析
- Author:
Qian ZHONG
1
;
Renyu ZHANG
2
;
Yongling ZHENG
2
Author Information
1. CCU of Department of Cardiology, the Third People's Hospital of Chengdu, Chengdu, Sichuan 610014, China
2. Department of Cardiology, the Third People's Hospital of Chengdu, Chengdu , Sichuan 610014, China
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Soluble growth stimulation expressed gene 2;
Albumin;
Prognosis
- From:
Journal of Public Health and Preventive Medicine
2026;37(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of levels of serum soluble growth stimulation expressed gene 2 (sST2) and albumin (ALB) in patients with chronic heart failure (CHF) and their correlation with prognosis. Methods The data of 216 patients with CHF (CHF group) and 98 healthy subjects with physical examination (healthy control group) were retrospectively analyzed. The changes in levels of serum sST2 and ALB between both groups and among different grades of New York Heart Association (NYHA), and their correlation with NYHA grading and cardiac function and their diagnostic value on the prognosis in patients with CHF were compared. Results The level of serum sST2 and LVEF value of CHF group were significantly higher than those of healthy control group (P<0.05) while the level of serum ALB was significantly lower than that of healthy control group (P<0.05). There were significant differences in the levels of serum sST2 and ALB and LVEF value among patients with different HYHA grades and pairwise comparison between the any two grades (P<0.05). Serum sST2 level in patients with CHF was positively correlated with NYHA grading (P<0.001) and was negatively correlated with LVEF (P<0.001), and serum ALB level was negatively correlated with NYHA grading (P<0.001), and was positively correlated with LVEF (P<0.001). Serum sST2 level of poor prognosis group was significantly higher than that of good prognosis group (P<0.05) while serum ALB level was significantly lower than that of good prognosis group (P<0.05). ROC curve analysis of serum sST2 combined with ALB in diagnosing poor prognosis in CHF patients showed that the AUC and sensitivity were 0.907 and 98.04%, which were higher than the single diagnosis, and the specificity was 81.82%, which was lower than the single diagnosis. Conclusion The levels of serum sST2 and ALB in patients with CHF are correlated with NYHA grading and cardiac function, and the combination of the two indicators has high diagnostic value on predicting the poor prognosis of patients.
