Research status of mitochondria-associated endoplasmic reticulum membranes in the pathogenesis of blinding ocular diseases
10.3980/j.issn.1672-5123.2026.3.08
- VernacularTitle:线粒体相关内质网膜在致盲性眼病发病机制中的研究现状
- Author:
Kewen ZHOU
1
;
Qingping LIU
1
;
Mingzhi ZHANG
1
Author Information
1. Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515041, Guangdong Province, China; Shantou University Medical College, Shantou 515041, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
mitochondria-associated endoplasmic reticulum membranes;
blinding ocular diseases;
mitochondrial dysfunction;
endoplasmic reticulum stress;
inflammatory response
- From:
International Eye Science
2026;26(3):410-416
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria-associated endoplasmic reticulum membranes(MAMs)are crucial structural links between the endoplasmic reticulum and mitochondria, formed by a complex protein network. They play a central role in cellular calcium signaling homeostasis, mitochondrial stability, endoplasmic reticulum stress, and inflammatory response. In recent years, advances in subcellular ultrastructure research techniques have gradually uncovered the relationship between MAMs dysfunction and blinding ocular diseases. Studies indicate that structural or functional impairments in MAMs can disrupt retinal pigment epithelial cells homeostasis, compromise the survival microenvironment of retinal ganglion cells, and trigger corneal endothelial cells apoptosis, thereby contributing to the pathogenesis of various blinding ocular diseases including age-related macular degeneration, diabetic retinopathy, Fuchs endothelial corneal dystrophy, and glaucoma. This article reviews the molecular mechanisms linking MAMs in common blinding ocular diseases.
