Current Status and Prospects of Research on Traditional Chinese Medicine Prevention and Treatment for Gastric Precancerous Lesions
10.13288/j.11-2166/r.2026.04.012
- VernacularTitle:胃癌前病变中医药防治研究现状及展望
- Author:
Haiyan BAI
1
;
Tai ZHANG
2
;
Ping WANG
3
;
Lin LIU
4
;
Weichao XU
1
;
Yaxin TIAN
1
;
Lanshuo HU
4
;
Qian YANG
1
;
Xudong TANG
4
Author Information
1. Hebei Hospital of Traditional Chinese Medicine，Shijiazhuang，050011
2. School of Clinical Medicine of Traditional Chinese Medicine （Xiyuan），Peking University
3. Xiyuan Hospital，China Academy of Chinese Medical Sciences
4. Institute of Spleen and Stomach Diseases，Xiyuan Hospital，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
gastric precancerous lesions;
traditional Chinese medicine therapy;
inflammation-carcinoma transformation;
literature review
- From:
Journal of Traditional Chinese Medicine
2026;67(4):410-415
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine （TCM）， through its multi-target and systematic regulatory effects， has demonstrated unique advantages in the treatment of gastric precancerous lesions （GPL）. At present， TCM theoretical research on GPL is mainly reflected in three aspects， the integration of macroscopic syndrome differentiation， the inflammation-carcinoma transformation mechanism， as well as the systematization and scientization of theoretical inheritance from famous TCM practitioners. High-quality evidence-based research findings serve as the foundation for clinical practice guidelines on GPL， and TCM has gained international academic recognition in the field of GPL prevention and treatment. Research on TCM mechanisms has yielded a series of important outcomes in the aspects of signaling pathways， gene expression regulation， cellular epigenetics， histone modification， and intestinal microecology. It is proposed that future research on GPL should focus on four key directions， establishing multi-omics data， exploring targeted intervention strategies on key regulatory nodes， advancing the standardization process of integrated traditional Chinese and western medicine prevention and treatment technologies， and constructing stratified screening and intervention platforms. The in-depth integration of TCM microcosmic mechanism of action with its macroscopic syndrome differentiation and treatment system， coupled with interdisciplinary research， will provide valuable references for the clinical treatment and scientific research of GPL.
