Dynamic Pathogenesis and Tiered Intervention Strategies for Allergic Diseases from the Perspective of "Latent Pathogens with Transformative Potential" Theory
10.13288/j.11-2166/r.2026.04.006
- VernacularTitle:“伏邪潜变”视域下过敏性疾病的病机演变及分层干预策略
- Author:
Minye QU
1
;
Ping ZHU
1
;
Kaifeng WEI
1
;
Yanliang ZHANG
2
;
Haitong WAN
2
;
Jin YANG
1
Author Information
1. Nanjing University of Chinese Medicine，Nanjing，210023
2. Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
allergic diseases;
latent pathogen;
sanjiao transmission and change;
accumulation of phlegm-stasis and toxins
- From:
Journal of Traditional Chinese Medicine
2026;67(4):375-380
- CountryChina
- Language:Chinese
-
Abstract:
Allergic diseases exhibited the characteristics of latent concealment and dynamic transmutation， which highly align with the pathogenic features of "latency and transformative change" described in the theory of latent pathogens. Based on the "latent pathogens with transformative potential" theory， this paper systematically explored the mechanisms of occurrence， transmission， and outcome of allergic diseases. It proposed that the insufficiency of kidney essence is the root cause enabling pathogens to lurk internally， leading to disease onset due to deficient healthy qi and lurking pathogens； the dysfunction of sanjiao serves as the pathway for pathogen stagnation， driving multi-system transmission； the accumulation of phlegm， stasis， and toxins constitutes the predicament of a protracted course， ultimately resulting in intractable pathological entanglement. Accordingly， a tiered intervention strategy is formulated，i.e. during the latency period， treatment should tonify the kidney and replenish essence to consolidate the foundation and halt the tendency of pathogens to lurk internally； during the transmission period， treatment should regulate sanjiao to intercept disease transmission and curb multi-system proliferation； during the protracted period， treatment should purge phlegm and resolve stasis to eliminate stubborn lesions， and break the vicious cycle of chronic accumulation and damage.
