Intervention Strategies for Heart Failure with Preserved Ejection Fraction Using Combined Classical Formulas Based on the Theory of "Disease of Both Blood and Water"
10.13288/j.11-2166/r.2026.04.005
- VernacularTitle:基于“血水同病”理论探析经方叠用辨治射血分数保留的心力衰竭干预策略
- Author:
Yuzhi JIA
1
;
Qingyong HE
1
;
Jie WANG
1
;
Xin ZHAO
1
;
Ziyi WANG
1
;
Dongmei LI
1
;
Junqiao AN
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
- Publication Type:Journal Article
- Keywords:
heart failure with preserved ejection fraction;
Zhenwu Decoction （真武汤）;
Guizhi Fuling Pills （桂枝茯苓丸）;
Tingli Dazao Xiefei Decoction （葶苈大枣泻肺汤）;
disease of both blood and water
- From:
Journal of Traditional Chinese Medicine
2026;67(4):370-374
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of "disease of both blood and water" in Essentials from the Golden Cabinet （《金匮要略》）， and in combination with the dynamic syndrome evolution of heart failure with preserved ejection fraction （HFpEF）， this paper systematically clarifies the pathomechanism of HFpEF， characterized by yang deficiency as the root， blood stasis as the pivotal factor and water retention as the manifestation. Accordingly， the therapeutic principles have been proposed， which are warming yang and banking up original qi to consolidate the root， activating blood and unblocking collaterals to smooth the mechanism， and promoting urination and regulating pivot to remove the branch. On this basis， a compound formula structure of "one monarch， one minister and one assistant" is established， forming an integrated intervention strategy that synergistically combines the three methods of warming yang， activating blood， and promoting urination through combined classical formulas. Zhenwu Decoction （真武汤）， which warms yang and dissolves rheum， is used to consolidate the root and directly target the source of yang deficiency， serving as the monarch； Guizhi Fuling Pills （桂枝茯苓丸）， which activates blood， promotes urination and unblocks the pivot， assists in interrupting the binding of blood stasis and water retention， serving as the minister； Tingli Dazao Xiefei Decoction （葶苈大枣泻肺汤）， which regulates qi， disperses retained fluids， and eliminates the manifestation， alleviates acute water-retention symptoms， serving as the assistant. This compound formula is warming without being drying， diuretic without being drastic， and dispels stasis without consuming blood， thereby achieving the therapeutic effects of warming yang， activating blood， and promoting urination.
