Research Progress in the Diagnosis and Treatment of Pancreatic Acinar Cell Carcinoma

Wenfei LI; Yuan XIE; Liyang MO; Junjie DANG; Qi WANG; Yang YANG; Qiuying SUN; Zhenping WEN; Sai GE; Xiaotian ZHANG

Return

Research Progress in the Diagnosis and Treatment of Pancreatic Acinar Cell Carcinoma

VernacularTitle:胰腺腺泡细胞癌诊断与治疗的研究进展
Author: Wenfei LI ¹ ; Yuan XIE ² ; Liyang MO ³ ; Junjie DANG ² ; Qi WANG ³ ; Yang YANG ³ ; Qiuying SUN ³ ; Zhenping WEN ² ; Sai GE ⁴ ; Xiaotian ZHANG ⁴
Author Information

1. Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China;.
2. Department of Gastrointestinal Oncology, Peking University Cancer Hospital Inner Mongolia Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University), Hohhot 010020, China;.
3. Department of Rare Tumor & Early-Phase Clinical Unit, Peking University Cancer Hospital Inner Mongolia Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University), Hohhot 010020, China;.
4. Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China;Department of Rare Tumor & Early-Phase Clinical Unit, Peking University Cancer Hospital Inner Mongolia Hospital (Affiliated Cancer Hospital of Inner Mongolia Medical University), Hohhot 010020, China;.
Publication Type:Journal Article
Keywords: pancreatic acinar cell carcinoma; diagnosis; treatment; targeted therapy; immunotherapy
From: JOURNAL OF RARE DISEASES 2025;4(4):437-445
CountryChina
Language:Chinese
Abstract:
Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas with distinct clinical and pathological features. In recent years, advancements in molecular biology techniques have led to a deeper understanding of the molecular mechanisms underlying PACC. Progress in imaging, endoscopic, and molecular diagnostic technologies has improved the early detection rate of PACC. The primary treatment modalities for PACC include surgical resection, chemotherapy, targeted therapy and immunotherapy; however, the therapeutic efficacy still requires further improvement. This article reviews the current research status of PACC, covering its epidemiology, pathological characteristics, molecular alterations, diagnostic methods, and treatment strategies, and discusses the controversies and future directions in PACC research.