Characteristics of 456 severe acute respiratory infection cases in Pudong New Area， Shanghai， 2023
10.19428/j.cnki.sjpm.2025.25095
- VernacularTitle:2023年上海市浦东新区456例严重急性呼吸道感染病例特征
- Author:
Zou CHEN
1
;
Liping CHAI
1
;
Yifeng SHEN
1
;
Chuchu YE
1
;
Yuanping WANG
1
;
Bing ZHAO
1
;
Qi ZHAO
2
;
Hong ZHANG
3
;
Lipeng HAO
1
Author Information
1. Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Pudong Institute of Preventive Medicine, Fudan University, Shanghai 200136, China
2. School of Public Health, Fudan University, Shanghai 200032, China
3. Pudong New Area Patriotic Health Campaign and Health Promotion Guidance Center, Shanghai 200136, China
- Publication Type:Journal Article
- Keywords:
severe acute respiratory infection;
inpatient;
SARS-CoV-2;
clinical manifestation;
positive rate
- From:
Shanghai Journal of Preventive Medicine
2025;37(12):1044-1047
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo retrospectively analyze the association between novel coronavirus (“SARS-CoV-2”) infection and clinical symptoms in inpatients with severe acute respiratory infection (SARI) in Pudong New Area, Shanghai, so as to provide evidence for improving clinical diagnostic ability. MethodsFrom January 13 to March 2, 2023, respiratory tract specimens of 456 inpatients with SARI were collected from 8 sentinel institutions, SARS-CoV-2 was detected by real-time fluorescence quantitative PCR. Whole genome sequencing and sequence analyses were performed to samples with a cycle threshold (Ct) value of <35. At the same time, demographic information, clinical characteristics and underlying disease condition of the cases were collected, and the association between age, symptoms and nucleic acid positive rates was evaluated by χ2 test and Spearman correlation analysis. ResultsA total of 456 cases were included, the median (P25, P75) age was 70 (69, 85) years old, of which 200 cases were novel coronavirus nucleic acid positive for SARS-CoV-2, with a positive rate of 43.86%. The positive rate was the highest in the 80-year-old group (56.82%), and the positive rate increased significantly with age (r=0.15, P=0.002). The proportion of oppression in chest, sore throat and expectoration in novel coronavirus nucleic acid positive cases was significantly higher than that in negative cases (all P<0.05). The 33 viruses sequenced successfully were all Omicron subvariants, with BF.7 (51.52%) and BA.5.2 (42.42%) being the predominant ones. ConclusionA positive correlation was observed between advanced age and the risk of SARS-CoV-2 positivity in patients with SARI. The symptoms of expectoration, oppression in chest and sore throat are more common in positive cases, which can be used as a prompt indicator for key screening and clinical identification of elderly SARI cases.
