The mechanisms underlying the impact of erythrocytes on coagulation and thrombus formation
10.13303/j.cjbt.issn.1004-549x.2026.01.022
- VernacularTitle:红细胞对凝血与血栓形成的影响机制
- Author:
Haolin MIN
1
;
Hua LU
2
Author Information
1. Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
2. Department of Blood Transfusion, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
- Publication Type:Journal Article
- Keywords:
red blood cells;
blood coagulation;
thrombosis
- From:
Chinese Journal of Blood Transfusion
2026;39(1):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Red blood cells (RBCs), as a key component determining the hemorheological properties, play a significant role in the dynamic process of thrombosis by regulating blood viscosity, shear stress distribution, and complex molecular mechanisms (including promoting platelet activation, mediating interactions with vascular endothelial cells, and releasing procoagulant factors). This article systematically elucidates the multidimensional mechanisms of RBCs in hemostasis and thrombus formation by integrating perspectives from hemorheology and molecular biology. It focuses on analyzing how their physical properties and molecular activities dynamically interact and mutually regulate under hemodynamic conditions, collectively forming a complex thrombus formation network. This provides a comprehensive understanding of the pathophysiology of RBCs involvement in coagulation and offers references for developing bleeding and thrombotic risk assessment strategies, as well as precision diagnosis and treatment approaches that incorporate RBCs functions.
