Cold-stored platelets：activity changes, preservation techniques and clinical application progress
10.13303/j.cjbt.issn.1004-549x.2026.01.021
- VernacularTitle:冷藏血小板的活性变化、保存技术及临床应用进展
- Author:
Yujie WEN
1
;
Yanjun JIA
1
Author Information
1. Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
- Publication Type:Journal Article
- Keywords:
cold-stored platelet;
activity changes;
preservation techniques;
clinical applications
- From:
Chinese Journal of Blood Transfusion
2026;39(1):136-140
- CountryChina
- Language:Chinese
-
Abstract:
Research has confirmed that compared to traditional room temperature-stored platelets [RTP, (22±2) ℃], cold-stored platelets (CSP, 1-6℃) extend the stored time by inhibiting bacterial proliferation, representing an important strategy to break through the bottleneck of platelet storage. However, the low temperature environment induces significant changes in platelet morphology, metabolism and function. The morphological changes and surface marker changes together lead to functional impairment, which in turn affect its hemostatic efficacy. In recent years, research on metabolomics, apoptosis mechanisms, and innovative preservation strategies and technologies has provided new perspectives for intensive analysis of the damage mechanisms of CSP. This review summarizes the changes in CSP performance, active components, and damage mechanisms, explores the research progress in preservation solutions and methods, and combines them with the current clinical application status. The aim is to provide a theoretical basis for intensive analysis of CSP performance changes and optimization of platelet storage strategies, and promote the application of CSP based on its functional characteristics in emergency treatment of active bleeding patients in China.
