A review on animal models of inherited thrombocytopenia
10.13303/j.cjbt.issn.1004-549x.2026.01.020
- VernacularTitle:遗传性血小板减少症动物模型研究进展
- Author:
Xiaojie WANG
1
;
Zhongjun LI
1
;
Li CHEN
1
Author Information
1. Department of Transfusion Medicine, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, China
- Publication Type:Journal Article
- Keywords:
inherited thrombocytopenia;
mouse model;
zebrafish model;
primate animal model
- From:
Chinese Journal of Blood Transfusion
2026;39(1):128-135
- CountryChina
- Language:Chinese
-
Abstract:
Inherited thrombocytopenia is a group of heterogeneous inherited diseases mainly characterized by platelet count defects. It is a monogenic disease caused by mutations in various genes. Animal models are crucial for studying the pathogenesis and treatment strategies of inherited thrombocytopenia. Previous reviews on animal models of inherited thrombocytopenia have mostly focused on a single species, such as mice or zebrafish. This article systematically summarizes the construction, phenotypes, and characteristics of multiple animal models (mice, zebrafish, and primate animal) of inherited thrombocytopenia-causing genes, thereby providing a systematic reference for a comprehensive understanding of the research progress of its animal models.
