Analysis of high-frequency plateletpheresis on age-dependent bone metabolism in female donors
10.13303/j.cjbt.issn.1004-549x.2026.01.014
- VernacularTitle:高频血小板单采对女性献血者年龄依赖性骨代谢影响的分析
- Author:
Huibin ZHONG
1
;
Huaheng LI
1
;
Wei YANG
1
;
Jieting HUANG
1
;
Zhen WANG
1
;
Fenfang LIAO
1
;
Yongmei NIE
1
Author Information
1. Guangzhou Blood Center, The Key Medical Disciplines and Specialties Program of Guangzhou, Guangzhou 510095, China
- Publication Type:Journal Article
- Keywords:
plateletpheresis;
female blood donors;
bone metabolism
- From:
Chinese Journal of Blood Transfusion
2026;39(1):97-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore whether the long-term and frequent use of citrate anticoagulants negatively affects the bone metabolism balance of female frequent plateletpheresis donors, so as to better protect their health. Methods: A total of 65 female plateletpheresis donors and 55 female whole-blood donors from Guangzhou Blood Center (May to December 2024) were enrolled as experimental and control groups respectively, stratified into age subgroups (18-39 years and 40-60 years). Serum levels of 25-hydroxyvitamin D [25(OH)D], procollagen type I N-terminal propeptide (PINP), osteocalcin (OC), and type I collagen carboxy-terminal telopeptide (CTX) were measured. Differences in bone metabolism markers between experimental and control groups across age subgroups were compared. ANOVA was used to analyze dose-response relationships between donation age, annual apheresis donation frequency, and biochemical indicators. Results: In the 40-60 age subgroup, 25(OH)D levels were significantly lower in the experimental group (P<0.05), exhibiting a linear increase with age and a linear decrease with annual donation frequency. No significant differences in CTX or PINP levels were observed between experimental and control groups in either age subgroup. Conclusion: High-frequency plateletpheresis donation does not disrupt bone metabolic balance in female donors. However, it is associated with reduced vitamin D levels in female donors aged >40 years, potentially increasing the risk of osteoporosis. Vitamin D supplementation is recommended for high-frequency female plateletpheresis donors in this age group.
