Treatment of Alzheimer's Disease with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20251842
- VernacularTitle:中药治疗阿尔茨海默病的研究进展
- Author:
Zheng XU
1
;
Yuan TANG
1
;
Fenglan QIU
2
;
Yiguang LI
1
;
Lingyu YANG
2
;
Jie CHEN
1
Author Information
1. School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330000， China
2. Jiangzhong Pharmaceutical Co. Ltd.， Nanchang 330000， China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
traditional Chinese medicine;
traditional Chinese medicine compound prescriptions;
mechanism of action;
neuroinflammation;
intestinal microbiota
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(4):322-330
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease （AD） is a common type of dementia， primarily characterized by cognitive and behavioral impairments as well as deficits in learning and memory. The progression of AD has imposed a significant economic burden on society and families. However， its exact pathogenesis has not yet been fully elucidated. Currently， available therapeutic drugs are limited and are often accompanied by serious adverse effects. Traditional Chinese medicines （TCMs） and their extracts are mostly natural products and possess advantages such as multi-pathway regulation and relatively few adverse reactions. Experimental studies have shown that TCMs exhibit great potential in the prevention and treatment of AD. For example， Huanglian Jieduang， Danggui Shaoyaosan， Kaixin San， Liuwei Dihuangwan， Buyang Huanwutang， as well as Ginseng Radix et Rhizoma， Astragali Radix， Uncariae Ramulus cum Uncis， Coptidis Rhizoma， Gardeniae Fructus， Ginkgo Folium， Salviae Miltiorrhizae Radix et Rhizoma， and Curcumae Longae Rhizoma， can reduce β-amyloid deposition， inhibit excessive Tau protein phosphorylation， restore mitochondrial function， alleviate oxidative stress， suppress neuroinflammation and apoptosis， repair synaptic function， and improve gut microbiota. This article mainly summarizes the effects of several TCMs and compound prescriptions on AD， aiming to provide a reference for subsequent TCM-based treatment of AD.
