Regulation of NLRP3 Inflammasome by Traditional Chinese Medicine in Treatment of Atopic Dermatitis： A Review
10.13422/j.cnki.syfjx.20250937
- VernacularTitle:中医药调控NLRP3炎性小体治疗特应性皮炎研究进展
- Author:
Minmin HU
1
;
Aimin LIU
2
;
Mengying MA
1
;
Changyu WU
1
Author Information
1. The Second Clinical Medical College， Henan University of Chinese Medicine， Zhengzhou 450002，China
2. Henan Province Hospital of Traditional Chinese Medicine， Zhengzhou 450011，China
- Publication Type:Journal Article
- Keywords:
atopic dermatitis;
traditional Chinese medicine;
NOD-like receptor pyrin domain-containing 3 （NLRP3） inflammasome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(4):315-321
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis （AD） is an atopic disease with a complex etiology and pathogenesis resulting from the interaction of multiple factors. The NOD-like receptor pyrin domain-containing 3 （NLRP3） inflammasome is an important component of innate immunity and is involved in the onset and progression of AD， encompassing multiple processes such as inflammation， pyroptosis， and autophagy. Traditional Chinese medicine （TCM） has shown significant clinical efficacy in the treatment of AD and also offers advantages including flexible compatibility， multi-target effects， and low drug resistance. A large number of studies have shown that single Chinese medicinal components and compound prescriptions can treat atopic diseases by modulating the NLRP3 inflammasome. This article elaborates on the activation of the NLRP3 inflammasome and its influence on the pathogenesis and progression of AD， and summarizes recent studies on the mechanisms by which active constituents， extracts， and compound formulations of Chinese medicine treat AD through regulation of the NLRP3 inflammasome and related signaling pathways， with the aim of providing a reference for the clinical treatment of AD and the development of TCM.
