Chaihu Guizhi Ganjiangtang and Its Single Active Ingredient in Treatment of Dyspepsia Caused by Chronic Cholecystitis： A Review
10.13422/j.cnki.syfjx.20251694
- VernacularTitle:柴胡桂枝干姜汤及其单味药有效成分治疗慢性胆囊炎消化不良的研究进展
- Author:
Wenwen YANG
1
;
Yubei LU
2
;
Lin CHEN
1
;
Jing ZHANG
3
;
Ying GAO
1
;
Yajuan ZHANG
1
;
Xiaoyan LI
1
;
Jianfei YANG
1
;
Xiaoli SHI
1
;
Huanhuan LIN
1
Author Information
1. School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China
2. Diagnosis and Treatment Center of Spleen and Stomach Diseases，Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，China
3. Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
Chaihu Guizhi Ganjiangtang;
active ingredients;
chronic cholecystitis;
dyspepsia;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(4):289-298
- CountryChina
- Language:Chinese
-
Abstract:
Chaihu Guizhi Ganjiangtang was first recorded in the Treatise on Cold Damage （Shang Han Lun）. This prescription is composed of Bupleuri Radix， Scutellariae Radix， Cinnamomi Ramulus， Zingiberis Rhizoma， Trichosanthis Radix， Ostreae Concha， and Glycyrrhizae Radix et Rhizoma. It has the effects of soothing Lesser Yang， warming the spleen， and stimulating the generation of body fluid. It is mainly used to treat digestive tract diseases such as chronic cholecystitis （CC）， irritable bowel syndrome， and non-alcoholic fatty liver disease. Dyspepsia caused by CC presents a variety of gastrointestinal symptoms such as abdominal pain， poor appetite， postprandial fullness， aversion to greasy food， soft stool， and bitter mouth， being a type of biliary dyspepsia. In modern medicine， dyspepsia caused by CC is mainly managed by medical treatment and surgical treatment. Internal medicine mainly focuses on reducing inflammation， promoting the function of gallbladder， resolving stones， alleviating spasms， and relieving the pain for CC， demonstrating definite short-term efficacy but suffering from single effects， high recurrence rate， and poor compliance. Although surgical treatment can cure cholecystitis， it is accompanied by the increased incidence of adverse events such as abdominal pain， diarrhea， and dyspepsia. Modern clinical studies have confirmed that Chaihu Guizhi Ganjiangtang can significantly alleviate the symptoms such as abdominal pain and dyspepsia of CC patients. Pharmacological studies have found that Chaihu Guizhi Ganjiangtang mainly contains active ingredients such as Bupleuri Radix saponins， baicalin， cinnamaldehyde， gingerol， Trichosanthis Radix polysaccharide， Ostreae Concha polysaccharide， and Glycyrrhizae Radix et Rhizoma total flavonoids. Chaihu Guizhi Ganjiangtang can ameliorate the symptoms of dyspepsia caused by CC by inhibiting inflammatory responses， improving gallbladder contraction and gastrointestinal motility， regulating the bile acid-intestinal flora axis and the brain-gut axis， and modulating blood lipids through multiple targets. By reviewing the previous literature， this article summarizes the research progress in the treatment of dyspepsia caused by CC with Chaihu Guizhi Ganjiangtang and its main active ingredients as well as the pathogenesis of this disease and puts forward the shortcomings and improvement strategies for the current research. The review aims to provide a reference for the further research on Chaihu Guizhi Ganjiangtang in the treatment of dyspepsia caused by CC.
