Hotspots in basic and translational research of gastric cancer
10.16139/j.1007-9610.2023.01.02
- VernacularTitle:胃癌基础与转化研究的热点问题
- Author:
Jianfang LI
;
Junxian YU
;
Chao YAN
;
Zhenggang ZHU
;
Bingya LIU
- Publication Type:Journal Article
- From:
Journal of Surgery Concepts & Practice
2023;28(1):7-16
- CountryChina
- Language:Chinese
-
Abstract:
The morbidity and mortality of gastric cancer are high, while the overall therapeutic effect is poor without satisfactory. Clinical obstacles, such as low early-diagnosis rate, tumor heterogeneity, lack of accurate classification and precise treatment, therapeutic resistance, recurrence and metastasis, are the key point issues to the lower efficacy in treatment of gastric cancer. In order to solve these clinical problems, it is necessary to devote more energy to the basic research of gastric cancer, including tumor genomics; gene editing; tumor microenvironment; inflammation, aging and tumor; cell differentiation disorders; autophagy and cell death; metabolic disorders; immunotherapy and drug development. This paper will summarize the clinical obstacles in the treatment of gastric cancer, and describe the directions of basic research on these clinical problems in future, so as to provide notions for the translational research of gastric cancer.
