The fifth edition of WHO classification of digestive system tumors: update and progress on biliary system tumors
10.16139/j.1007-9610.2023.02.08
- VernacularTitle:第5版WHO消化系统肿瘤分类解读：胆道系统肿瘤的更新及进展
- Author:
Fangxiu LUO
;
Qianchen MA
;
Fei YUAN
- Publication Type:Journal Article
- From:
Journal of Surgery Concepts & Practice
2023;28(2):124-131
- CountryChina
- Language:Chinese
-
Abstract:
Overall, there was little change in biliary system tumors of the 5th edition of WHO classification of digestive system tumors after update. The three-tiered classification of biliary intraepithelial neoplasia changed to two-tiered system: high-grade and low-grade, in the section of benign tumors and precancerous lesions. And both intracholecystic and intraductal papillary tumors associated with invasive carcinoma were added. The classification of intrahepatic bile duct tumors introduced parts of bile duct adenoma and bile duct adenofibroma, which were mentioned previously in the differential diagnosis with bile duct carcinoma. Intrahepatic cholangiocarcinoma was divided into small bile duct subtype and large bile duct subtype in the 5th edition of WHO classification, and the names of cholangiocellular carcinoma and cholangiole cell carcinoma were no longer recommended to use. Extrahepatic cholangiocarcinoma was listed as a separate part for the first time, including squamous cell carcinoma, adenosquamous carcinoma and undifferentiated carcinoma in addition to common histological types. Some new contents of molecular pathology in the 5th edition of WHO classification were added, which provided the basis for precise classification and diagnosis of tumors in biliary system.
