Correlation between salivary ANG-2 level and inflammation activity of oral lichen planus
10.13591/j.cnki.kqyx.2025.01.007
- VernacularTitle:唾液ANG-2浓度和口腔扁平苔藓炎症活跃程度的关联性分析
- Author:
Yuanyi XIANG
1
;
Jingjing LUO
;
Haiyang LI
;
Zhongting WU
;
Hongmei ZHOU
Author Information
1. 口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,"口腔医学+"前沿医学创新中心,四川大学华西口腔医院口腔黏膜病科,四川成都(610041)
- Keywords:
oral lichen planus;
inflammatory activity;
angiopoietin 2;
saliva;
non-invasive monitoring
- From:
STOMATOLOGY
2025;45(1):45-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assay the salivary ANG-2 level of oral lichen planus(OLP)patients,and analyze its correlation with in-flammatory activity of OLP.Methods Eighty-nine OLP patients were included,and divided into four subgroups as non-erosive asymp-tomatic(NEA),non-erosive symptomatic(NES),minor-erosive(MIE)and major-erosive(MAE)groups.Fifteen healthy adults were recruited as controls.Whole unstimulated saliva was collected from each participant,and the salivary ANG-2 level was measured by chemiluminescence immunoassays(CLIA)for analysis.Normal oral mucosal tissue,non-erosive and erosive OLP tissues were collected to detect and analyze the expression of ANG-2 positive blood vessels by immunohistochemistry(IHC).Results The base-lines of age and gender between OLP and control groups showed no significant difference.Compared to controls,the salivary ANG-2 levels of OLP group,non-erosive and erosive OLP subgroups were significantly higher(P＜0.05),in which erosive OLP group was higher than non-erosive OLP group(P=0.022);NES subgroup was slightly higher than NEA(P=0.048),and there was no statistical significance between MIA and MEA subgroups(P=0.067).Spearman correlation analysis showed a positive correlation between sali-vary ANG-2 level and inflammation activity in OLP patients(r=0.314,P=0.003).The expression of ANG-2 in non-erosive OLP mu-cosal tissues slightly increased than normal oral mucosal tissue(P＞0.05),but there was no significant difference.The expression of ANG-2 in erosive OLP mucosal tissues significantly increased than normal oral mucosal tissue(P＜0.001)and non-erosive OLP group(P＜0.001).Conclusion There is a certain correlation between sali-vary ANG-2 level and inflammatory activity of OLP,indicating that salivary ANG-2 level is probable to be one of the inflammatory activity indicators to monitor the state-variation of OLP as a clinical non-inva-sive method.
