Research Status and Clinical Application Progress of Peptide Drugs
10.12259/j.issn.2095-610X.S20251119
- VernacularTitle:肽类药物的研究现状及临床应用进展
- Author:
Qiqi PEI
1
;
Qian CHEN
;
Hanying WANG
;
Li TIAN
;
Guizhu FENG
Author Information
1. 昆明医科大学基础医学院,云南 昆明 650500
- Keywords:
Peptide drugs;
Research status;
Clinical application;
Limitations;
Therapeutic targets
- From:
Journal of Kunming Medical University
2025;46(11):148-159
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing difficulty of traditional chemical drug research and development,peptide drugs have gradually become a hot spot in drug research and development due to their advantages of high specificity,significant efficacy,easy metabolism and low toxicity.This review systematically expounds the physicochemical properties,main advantages and limitations of peptide drugs,and summarizes the currently common strategies for structural modification and delivery.It focuses on the application and target of approved peptide drugs in various diseases such as diabetes,cancer,bacterial and viral infections,multiple sclerosis,and osteoporosis.Furthermore,the research analyzes the challenges in the research and development of peptide drugs,including poor in vivo stability,low bioavailability,and limited routes of administration.It also discusses the prospects of new technologies based on molecular modification,nanodelivery systems,and computer-aided design.In summary,peptide drugs have shown unique advantages in multi-field therapy,but they still need to break through bottlenecks in preparation,delivery and drug resistance to provide new ideas and directions for future precision therapy.
