Infection Mechanism and Detection of Occult Hepatitis B Virus in Voluntary Blood Donors
10.12259/j.issn.2095-610X.S20251017
- VernacularTitle:无偿献血者隐匿性HBV感染机制和检测研究进展
- Author:
Pei LIU
1
;
Boyu ZHANG
;
Wei LI
;
Youbin DUAN
Author Information
1. 云南昆明血液中心血液供应科,云南 昆明 650500
- Keywords:
Voluntary blood donors;
Blood transfusion safety;
Occult hepatitis B;
High-throughput sequencing
- From:
Journal of Kunming Medical University
2025;46(10):137-144
- CountryChina
- Language:Chinese
-
Abstract:
The risk of post-transfusion hepatitis(PTH)primarily stems from blood transfusion containing HBV-infected blood that is HBsAg-negative,specifically during the serological window period(WP)and occult HBV infection(OBI).OBI is a low viral replication form of HBV,making it a challenge in hepatitis B virus infection prevention and control,and a significant transmission source of post-transfusion hepatitis.Although nucleic acid testing(NAT)can reduce the occurrence of post-transfusion hepatitis to some extent,some OBI-infected individuals exist among blood donors,representing a potential risk of HBV transmission through blood.This article primarily summarizes an overview of OBI's concept,serological characteristics,genomic features,pathogenesis mechanisms,epidemiological characteristics,and advances in detection strategies,to provide theoretical basis for the collection,quality control and safe use of blood products for the OBI population.
