Effects of Early Statin Therapy on Collateral Circulation,Responsible Vessels,and TXB2/PGF1α in Large Artery Occlusive Stroke
10.12259/j.issn.2095-610X.S20251016
- VernacularTitle:早期他汀类药物治疗大动脉闭塞性脑卒中对侧支循环、责任血管改善及TXB2/PGF1α的影响
- Author:
Fei YANG
1
;
Jing LI
;
Yanjun CHEN
;
Xuemei WU
;
Guoyong REN
Author Information
1. 太原钢铁(集团)有限公司总医院神经内科,山西 太原 030003
- Keywords:
Acute ischemic stroke with large vessel occlusion;
Statins;
Thromboxane B2;
Prostaglandin F1 alpha;
Collateral circulation
- From:
Journal of Kunming Medical University
2025;46(10):129-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of early statin therapy on collateral circulation,responsible vessel improvement,and thromboxane B2(TXB2)/prostaglandin F1(PGF1α)in acute ischemic stroke with large vessel occlusion(AIS-LVO).Methods From May 2021 to May 2023,105 AIS-LVO patients treated with statins within 3 days of admission were selected as the statin group from the Neurology Department of Taiyuan Iron and Steel(Group)General Hospital.Concurrently,105 early AIS-LVO patients not treated with statins were selected as the non-statin group.The study compared symptom scores[National Institutes of Health Stroke Scale(NIHSS),modified Rankin Scale(mRS),Swallowing Standard Assessment(SSA),and Functional Oral Intake Scale(FOIS)scores],responsible vessel improvement,TXB2/PGF1α levels,and endothelial function indicators[basic fibroblast growth factor(bFGF)and circulating endothelial cells(CECs)].Results Af-ter 1 and 2 weeks,the statin group showed lower NIHSS,mRS,and SSA scores,and higher FOIS scores compared to the non-statin group(P<0.02).The statin group demonstrated higher rates of responsible vessel velocity increase,collateral circulation compensation,and superior CTA collateral circulation grading(P<0.05).At 1 and 2 weeks,the statin group had lower TXB2 and TXB2/PGF1α levels,and higher PGF1α levels compared to the non-statin group(P<0.02).The statin group showed lower bFGF levels and higher CECs levels(P<0.02).After 3 months,the statin group had a higher proportion of mRS scores of 0～2(P<0.05).Conclusion Early statin therapy in AIS-LVO patients can improve responsible vessel blood flow and endothelial function,regulate TXB2/PGF1α levels,promote collateral circulation compensation,and enhance swallowing and neurological function recovery.
