Clinical Value of AI-Assisted Transvaginal Color Ultrasound Combined with Serum Markers in Diagnosing Heterotopic Pregnancy after IVF-ET
10.12259/j.issn.2095-610X.S20251014
- VernacularTitle:AI辅助阴道彩超联合血清标志物诊断IVF-ET后宫内外复合妊娠的临床价值
- Author:
Li ZHU
1
;
Heli LIU
;
Jian MAO
;
Bin ZHENG
;
Shuqun WANG
Author Information
1. 沧州中西医结合医院超声一科,河北 沧州 061000
- Keywords:
IVF-ET;
Heterotopic pregnancy;
Transvaginal color doppler ultrasound;
Artificial intelligence;
Serum biomarkers
- From:
Journal of Kunming Medical University
2025;46(10):113-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the early diagnostic value of AI-assisted transvaginal ultrasound combined with serum biomarkers for intrauterine and ectopic combined pregnancy(heterotopic pregnancy,HP)after IVF-ET.Methods This retrospective case-control study included 86 patients diagnosed with HP after IVF-ET at Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine between January 2022 and December 2024.Control groups consisted of 86 patients with normal intrauterine pregnancies and 86 patients with simple ectopic pregnancy.All patients were diagnosed through clinical diagnosis,imaging examinations,and surgical confirmation.An AI ultrasound image analysis model and serum markers(hCG,PAPP-A,APA,progesterone,PlGF)were used to jointly assess HP diagnostic efficiency.Diagnostic performance was compared by calculating sensitivity,specificity,positive predictive value,and negative predictive value.Results The AI ultrasound image analysis model's AUC was 0.835,significantly superior to traditional ultrasound(AUC=0.696).Serum hCG and PAPP-A levels were(36,210±9,820)IU/L and(0.81±0.25)μg/mL,respectively.The joint diagnostic AUC was 0.909,with a sensitivity of 94.2％,specificity of 88.4％,positive predictive value of 91.6％,and negative predictive value of 92.8％.Conclusion AI-assisted ultrasound combined with serological markers significantly improves the early diagnostic accuracy of HP,outperforming single methods and providing a reliable clinical tool.
