Clinical Application of NETs in Diagnosis and Monitoring of Acute Ischemic Stroke
10.12259/j.issn.2095-610X.S20251012
- VernacularTitle:NETs在急性缺血性脑卒中诊断和病情监测中的临床应用
- Author:
Wendi YANG
1
;
Yaxin WANG
;
Jing QIAN
;
Limin YIN
;
Fengting MU
;
Xiaoli ZHAO
Author Information
1. 昆明医科大学附属甘美医院/昆明市第一人民医院医学检验科,云南 昆明 650224
- Keywords:
Neutrophil extracellular traps;
Citrullinated histone H3;
Neutrophil elastase;
Myeloperoxidase
- From:
Journal of Kunming Medical University
2025;46(10):97-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of neutrophil extracellular trapping nets(neutrophil extracellular traps,NETs)in the diagnosis and monitoring of acute ischemic stroke(acute ischemic stroke,AIS).Methods From June 2023 to February 2024,63 patients newly diagnosed with AIS at the Ganmei Hospital Affiliated with Kunming Medical University were selected as the experimental group,and 58 non-AIS individuals matched in gender,age,and other characteristics were selected as the control group.The NETs levels of patients in the experimental group were detected before and 7-10 days after treatment,and general clinical data and related laboratory results were statistically analyzed.Results The experimental group showed significantly higher levels of NEUT,LYMPH,MONO,EO,FDP,D-dimer,and NETs compared to the control group(P<0.05).The NETs levels before treatment were significantly higher than those at 7～10 days after treatment and in the control group(P<0.05).The NETs levels 7～10 days after treatment were significantly higher than those in the control group(P<0.05).NEUT,MONO,FDP,D-dimer,and NIHSS scores were positively correlated with the pre-treatment NETs levels(P<0.05).Elevated serum NETs levels were associated with AIS risk factors(P<0.05).The combined diagnostic value of NEUT,D-dimer,and NETs for AIS was superior to other indicators.Conclusion NETs are highly expressed in the serum of patients with acute ischemic stroke,and serum NETs have certain value in the auxiliary diagnosis and monitoring of acute ischemic stroke.
