Predictive Value of Serum miRNA-126a and miRNA-130b Levels in Cognitive Impairment among Patients with Diabetes Mellitus Complicated with Acute Stroke
10.12259/j.issn.2095-610X.S20251011
- VernacularTitle:血清miRNA-126a及miRNA-130b水平对糖尿病合并急性脑卒中患者认知障碍的预测价值
- Author:
Lingli LIU
1
;
Ruoxuan WEI
;
Wei CHEN
;
Caixia KONG
;
Zhihong LIU
Author Information
1. 武汉市第一医院内分泌科,湖北 武汉 430000
- Keywords:
Diabetes;
Acute stroke;
Peripheral blood;
Cognitive impairment;
microRNAs
- From:
Journal of Kunming Medical University
2025;46(10):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum miRNA-126a,miRNA-130b levels and cognitive impairment(CI)in patients with diabetes mellitus(DM)complicated with acute stroke(AS).Methods A retrospective analysis was conducted on 70 DM patients with AS admitted to Wuhan First Hospital from January 2019 to December 2021.Patients were divided into CI group(41 cases)and non-CI group(29 cases)based on the occurrence of CI.Real-time fluorescence quantitative PCR was used to detect the relative expression levels of miRNA-126a and miRNA-130b in peripheral blood.Results Compared with non-CI group,the CI group showed increased albumin(P<0.05)and decreased levels of miRNA-126a and miRNA-130b(P<0.05).Logistic regression analysis showed that albumin(OR=19.045,95%CI=2.001～181.230),miRNA-126a(OR=200.603,95%CI=15.663～2569.162),miRNA-130b(OR=11.770,95%CI=1.966～70.474)were related factors affecting CI occurrence in DM patients with AS.ROC curve analysis showed that peripheral blood miRNA-126a had the highest AUC(0.958)for diagnosing CI in DM patients with AS,with a sensitivity of 97.6%and specificity of 89.7%.The AUC for miRNA-130b(0.669)was lower,with a sensitivity of 73.2%and specificity of 62.1%.Conclusion Decreased expression of peripheral blood miRNA-126a has good diagnostic value for CI in DM patients with AS.
