Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness
10.12259/j.issn.2095-610X.S20251001
- VernacularTitle:重复经颅磁刺激治疗慢性意识障碍的临床应用及潜在机制研究进展
- Author:
Jianlin PU
1
;
Jing FU
;
Zhong LI
;
Qiuyue MAO
;
Hongpeng LIU
;
Yadong LIU
;
Xuesong GAI
Author Information
1. 云南中医药大学第二临床医学院,云南 昆明 650500
- Keywords:
Repetitive transcranial magnetic stimulation;
Prolonged disorders of consciousness;
Concion-sness recovery;
Neuromodulation;
Action mechanism
- From:
Journal of Kunming Medical University
2025;46(10):1-11
- CountryChina
- Language:Chinese
-
Abstract:
Prolonged disorders of consciousness(pDoC)are complex and prolonged conditions that severely impact patient prognosis and remain a clinical treatment challenge.In recent years,neural regulation-based awakening therapies have been widely applied in the assessment and treatment of pDoC patients.Repetitive transcranial magnetic stimulation(rTMS)technology can regulate neural activity and improve patients'consciousness states,demonstrating positive awakening effects for pDoC patients.However,the optimal stimulation parameters and awakening mechanisms of rTMS remain unclear.This article reviews the pathological mechanisms of pDoC,clinical applications of rTMS at different targeting sites and stimulation frequencies,and focuses on exploring how rTMS promotes consciousness recovery through neural mechanisms such as altering neural pathways,reshaping brain networks,promoting synaptic plasticity and neurotransmitter release,regulating neurotrophic factor expression,and modulating cerebral hemodynamics.Based on artificial intelligence,the article also prospects the future clinical research applications of rTMS.
