Correlation and Diagnostic Performance of Inflammatory Cytokines in Relation to Bone Mineral Density and β-CTX in Postmenopausal Women with Type 2 Diabetes Mellitus
10.12259/j.issn.2095-610X.S20250909
- VernacularTitle:绝经后T2DM患者炎症因子与骨密度和β-CTX的相关性及诊断效能分析
- Author:
Kaige ZHANG
1
;
Ruonan LI
;
Jialin CHEN
;
Deping FENG
;
Yu LIU
Author Information
1. 大理大学临床医学院,云南 大理 671003;云南省第三人民医院内分泌科,云南 昆明 650011
- Keywords:
Inflammatory factors;
Postmenopausal type 2 diabetes mellitus;
Osteoporosis;
Correlation;
Diagnostic efficacy
- From:
Journal of Kunming Medical University
2025;46(9):81-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between inflammatory factors and bone mineral density(BMD)as well as β-C-terminal telopeptide of type I collagen(β-CTX)in postmenopausal patients with type 2 diabetes mellitus(T2DM),and to evaluate the diagnostic efficacy of the inflammatory factors in postmenopausal T2DM patients with osteoporosis(OP).Methods A total of 538 postmenopausal women with T2DM,hospitalized in the Department of Endocrinology at the Third People's Hospital of Yunnan Province from October 1,2023 to August 31,2024,were screened,and 181 were ultimately included in the study.Based on bone mineral density,they were divided into the osteopenia group(86 patients,-2.51,B>0),while BMI was an independent protective factor for the occurrence of OP(OR<1,B<0);(4)ROC curve analysis showed that CRP,IL-6,NLR,MLR,and SII all demonstrated diagnostic efficacy for postmenopausal T2DM patients with osteoporosis,among which the combined detection model of CRP,IL-6,and SII exhibited the highest diagnostic efficacy.Conclusion Inflammatory markers are correlated with bone mineral density and β-CTX levels,and may have predictive value for diagnosing osteoporosis in postmenopausal T2DM patients.
