Research Progress on the Role of Immune Cell Dysfunction in the Occurrence and Development of Liver Failure
10.12259/j.issn.2095-610X.S20250901
- VernacularTitle:免疫细胞功能紊乱在肝衰竭发生和发展中的研究进展
- Author:
Tangwei MOU
1
;
Dan LIANG
;
Yu ZHAO
;
Yiqun KUANG
Author Information
1. 昆明医科大学第一附属医院临床医学研究中心,云南 昆明 650032
- Keywords:
Liver failure;
Immune cell function;
Immune response;
Immunometabolism;
Targeted therapy
- From:
Journal of Kunming Medical University
2025;46(9):1-14
- CountryChina
- Language:Chinese
-
Abstract:
The liver,as the core metabolic organ of the human body,undertakes multiple critical physiological functions such as protein synthesis,xenobiotic metabolism,and immune regulation.Liver failure represents a major disease process in patients with end-stage liver disease,characterized clinically by coagulopathy,abnormal bilirubin metabolism,and multiple organ dysfunction.Depending on the disease course,liver failure can be classified into four types:acute,subacute,acute-on-chronic,and chronic.The pathogenic mechanisms are complex,involving interactions among various factors such as pathogen infections,dysregulation of the immune microenvironment,and gut microbiota disturbances,which pose significant challenges for clinical diagnosis and treatment.This review summarizes the abnormalities in innate and adaptive immune responses,as well as the molecular mechanisms of immune metabolic dysregulation during the occurrence and progression of liver failure.It further explores the pivotal role of immune cell dysfunction in the disease process,aiming to provide a theoretical basis for targeted immune therapies in liver failure.
