The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction
10.12259/j.issn.2095-610X.S20250801
- VernacularTitle:蛋白质乳酸化修饰在脓毒症器官障碍中的作用机制
- Author:
Couwen LI
1
;
Bing GONG
;
Runfei SHAO
;
Zhuange SHI
;
Lishun YANG
;
Guobing CHEN
Author Information
1. 昆明理工大学研究生院,云南 昆明 650500
- Keywords:
Protein lactylation modification;
Sepsis;
Multiple organ dysfunction
- From:
Journal of Kunming Medical University
2025;46(8):1-9
- CountryChina
- Language:Chinese
-
Abstract:
This article aims to explore the mechanism of protein lactate modification(Kla)in sepsis and multiple organ dysfunction syndrome(MODS).By regulating gene transcription and inflammatory factor expression,Kla participates in sepsis organ function damage,and can also destroy the cell structure and metabolic homeostasis,aggravating sepsis induced lung,kidney,heart,brain,liver organ damage.By conducting in-depth study on its mechanism,it will help to explore new therapeutic targets and provide innovative ideas for clinical treatment of sepsis.
