Efficacy of CO2 Fractional Laser Combined with Interferon in Treating Persistent High-Risk HPV Infection of the Cervix
10.12259/j.issn.2095-610X.S20250717
- VernacularTitle:CO2点阵激光联合干扰素治疗宫颈持续性Hr-HPV感染的疗效
- Author:
Xinghui CHEN
1
;
Lisha MA
;
Yuan WANG
;
Lichi ZHANG
;
Aiju CHEN
;
Hongxian LI
;
Junjing HE
Author Information
1. 昆明市妇幼保健院健康管理中心,云南 昆明 650031
- Keywords:
CO2 lattice laser;
Interferon;
Persistent high-risk HPV infection;
Vaginal microecology
- From:
Journal of Kunming Medical University
2025;46(7):139-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of intravaginal CO2 fractional laser combined with interferon in treating persistent high-risk HPV infection of the cervix and its impact on vaginal microecology.Methods A total of 211 patients with persistent high-risk HPV infection of the cervix who visited Kunming Maternal and Child Health Care Hospital from June 2022 to July 2024 were selected and randomly divided into a follow-up(blank control)group(n=70),an interferon treatment group(n=70),and a combined treatment group(n=71).The follow-up group received regular follow-ups.The interferon treatment group was treated with recombinant human interferon α-2b,and the combined treatment group received a combination of CO2 matrix laser and interferon treatment.The total effective rate,levels of inflammatory factors,and vaginal microecological recovery were compared among the three groups at 3 and 6 months after treatment.Results Overall efficacy:The overall efficacy rates of the combined treatment group at 3 months and 6 months were 73.24%and 81.69%,respectively,significantly higher than those of the interferon group(47.14%and 60.00%)and the blank control group(11.43%and 18.57%)(all P<0.001).Inflammatory factors:Post-treatment levels of IL-1 and TNF-α in the combined treatment group were significantly lower than those in the other two groups(P<0.001).Vaginal microbiota:The combined treatment group had a significantly higher rate of normal PH(84.51%)and normal lactobacillus levels(92.96%)compared to the other two groups(P<0.001).Conclusion CO2 lattice laser combined with interferon can effectively eliminate HPV,improve inflammation and vaginal microenvironment,and demonstrates superior efficacy to monotherapy,with good safety.
