The Role of Mitochondrial Function in Adipose Tissue in Obesity
10.12259/j.issn.2095-610X.S20250701
- VernacularTitle:脂肪组织线粒体功能在肥胖中的作用
- Author:
Ying QIAN
1
;
Jizhuo YANG
;
Juan HUANG
;
Kedi YUAN
;
Junyi LIU
;
Yuemei FENG
;
Jianzhong YIN
Author Information
1. 云南省公共卫生与生物安全重点实验室,云南 昆明 650500;昆明医科大学公共卫生学院,云南 昆明 650500
- Keywords:
Obesity;
Adipose tissue;
Mitochondrial dysfunction;
Metabolic disorders
- From:
Journal of Kunming Medical University
2025;46(7):1-9
- CountryChina
- Language:Chinese
-
Abstract:
Obesity has become a major global public health issue,and the situation in China is also becoming increasingly severe.Adipose tissue is categorized into white adipose tissue(WAT)and brown adipose tissue(BAT),which regulates metabolic homeostasis by secreting various adipokines.Mitochondria,as the core organelles of energy metabolism,its dysfunction are closely related to obesity.In the state of obesity,mitochondrial dynamics imbalance,oxidative stress,and metabolic dysfunction can all lead to energy metabolism disorders and adipose tissue dysfunction.Moreover,mitochondrial dysfunction not only affects adipose tissue but also extends to multiple organs such as muscles and livers,thereby exacerbating obesity and related metabolic diseases.In recent years,although numerous therapeutic strategies targeting mitochondrial dysfunction have been actively explored,their clinical translation faces challenges.This review explores the association between mitochondrial dysfunction in adipose tissue and obesity,analyses its mechanism and existing treatment strategies,aiming to provide a new perspective for the diagnosis and treatment of obesity.
