Expression and Prognostic Correlation Analysis of NUTF2 in Head and Neck Squamous Cell Carcinoma(HNSCC)Patients
10.12259/j.issn.2095-610X.S20250613
- VernacularTitle:NUTF2在HNSCC患者中的表达及与预后关系分析
- Author:
Shubin JIN
1
;
Xiaoyan LIU
;
Wenhua GENG
;
Jianjun JIAO
Author Information
1. 邯郸市中心医院口腔颌面外科,河北 邯郸 056001
- Keywords:
Head and neck squamous cell carcinoma;
Nuclear transport factor 2;
Tumor staging;
Prognosis
- From:
Journal of Kunming Medical University
2025;46(6):103-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of nuclear transport factor 2(NUTF2)in patients with head and neck squamous cell carcinoma(HNSCC)and analyze its relationship with prognosis.Methods 269 HNSCC patients from Handan Central Hospital between March 2016 and February 2017 were selected.Immunohistochemical staining was used to detect NUTF2 expression levels,comparing tumor tissues with adjacent tissues and NUTF2 expression across different tumor stages.The correlation between NUTF2 expression levels and tumor staging,as well as factors influencing HNSCC patient survival outcomes,were analyzed.Survival situations of HNSCC patients with different NUTF2 expression levels were compared.In vitro experiments were conducted to observe the effects of NUTF2 expression level changes on HNSCC cell proliferation and apoptosis.Results NUTF2 expression levels in HNSCC tumor tissues were higher than in adjacent tissues(P<0.05);NUTF2 expression levels were positively correlated with tumor staging(P<0.05).NUTF2 expression level(HR=3.478,95%CI 1.752～6.906)was a factor influencing HNSCC patient survival outcomes(P<0.05);HNSCC patients with high NUTF2 expression had lower survival rates compared to those with low NUTF2 expression(HR=0.486,95%CI 0.298～0.793,χ2=8.345,P=0.004).Knockdown of NUTF2 expression inhibited HNSCC cell proliferation and promoted cell apoptosis.Conclusion NUTF2 expression levels are abnormally elevated in HNSCC tumor tissues,directly affecting patient survival outcomes,with high NUTF2 expression indicating a poorer prognosis.
