Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases

VernacularTitle:PINK1/Parkin通路介导的线粒体自噬在神经退行性疾病发展中的影响研究
Author: Kongjia WU ¹ ; Shuqian DOU ; Yuan WANG ; Qi WANG ; Pan DU ; Wenjun LIU
Author Information

1. 昆明医科大学第二附属医院烧伤科,云南昆明 650032
Keywords: Mitophagy; Oxidative stress; Parkinson's; Alzheimer's disease
From: Journal of Kunming Medical University 2025;46(6):1-8
CountryChina
Language:Chinese
Abstract: Mitochondria not only serve as the central hub for cellular energy metabolism,but also participate in crucial physiological processes such as signal transduction and activity regulation.Abnormal mitochondrial quantity,imbalance in mtDNA copy number,accumulation of genetic mutations,and aberrant activation of autophagic pathways can lead to mitochondrial dysfunction or even organelle disorders,while activating mechanisms of cellular damage and death,consequently contributing to the pathogenesis of various diseases.As a highly selective form of autophagy,mitophagy plays a pivotal regulatory role in organelle quality control and homeostasis maintenance.This article focuses on the classic PINK1/Parkin pathway-mediated mitophagy as an entry point,summarizing recent research advances regarding the role of mitophagy in neurodegenerative diseases,aiming to provide novel insights for developing targeted mitophagy regulation strategies to improve prevention and treatment approaches for neurodegenerative disorders.