Correlation between Glycolytic Pathway of Monocytes and Intracranial Pressure and Clinical Prognosis in Patients with Hypertensive Cerebral Hemorrhage
10.12259/j.issn.2095-610X.S20250513
- VernacularTitle:单核细胞糖酵解通路表达与高血压脑出血患者颅内压及临床预后的相关性
- Author:
Hongsha PEI
1
;
Mingyang XU
;
Baoming JIA
;
Jianlong SU
;
Yigong FENG
;
Sibo XUE
;
Zhijun SONG
Author Information
1. 邢台市中心医院神经外科四病区,河北 邢台 054000
- Keywords:
Peripheral blood mononuclear cells;
Hypertensive cerebral hemorrhage;
Break into the ventricle;
Intracranial pressure;
Prognosis
- From:
Journal of Kunming Medical University
2025;46(5):110-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between glycolysis related indexes of peripheral blood mononuclear cells(PBMCs)[glucose transporter 1(GLUT1),fructose-2,6-diphosphatase 3(PFKFB3)and lactate kinase M2(PKM2)]and intracranial pressure and clinical prognosis of patients with hypertensive cerebral hemorrhage(HICH)who broke into the ventricle.Methods 85 HICH patients hospitalized in our hospital from January 2021 to June 2022 were retrospectively collected as the research participants.The levels of PKM2,GLUT1 and PFKFB3 in PBMCs were analyzed by enzyme-linked immunosorbent assay kit.Six months after the onset of HICH,the short-term outcome was evaluated by modified Rankin scale(mRS),and the patients were divided into good prognosis(mRS score≤2)and poor prognosis(mRS score≥3).Results The levels of PKM2,PFKFB3 and GLUT1 in PBMCs of HICH patients with ventricular rupture were further lower than those of the patients without ventricular rupture(P<0.05).Six months after discharge,8 patients(22.9%)with HICH in non-ventricular rupture group had poor prognosis,while 28 patients(56.0%)with HICH in ventricular rupture group had poor prognosis,and the difference was statistically significant(χ2=9.263,P=0.002).Compared with the group with good prognosis,the levels of PKM2 and GLUT1 in PBMCs of HICH patients with poor prognosis were lower(P<0.05).Compared with the good prognosis group,the levels of PKM2 and GLUT1 in PBMCs of HICH patients with poor prognosis group were lower in HICH patients with ventricular rupture(P<0.05).In HICH patients who broke into the ventricle,the AUC of PKM2 and GLUT1 in predicting the poor prognosis of HICH patients were 0.879(95%CI:0.807～0.951)and 0.897(95%CI:0.831～0.963),respectively.Conclusion The levels of PKM2 and GLUT1 in PBMCs of patients with HICH breaking into ventricles decrease significantly,and are negatively correlated with intracranial pressure,which can be used to predict the short-term prognosis of the patients.
