Research Progress of Immunosuppression Mechanism and Immunotherapy in Sepsis
10.12259/j.issn.2095-610X.S20250501
- VernacularTitle:脓毒症免疫抑制机制及免疫治疗的研究进展
- Author:
Guangxian HUANG
1
;
Yijie WANG
Author Information
1. 昆明医科大学第一附属医院老年重症医学科,云南 昆明 650032
- Keywords:
Sepsis;
Immunosuppression;
Immunotherapy;
Epigenetic dysregulation
- From:
Journal of Kunming Medical University
2025;46(5):1-11
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a syndrome caused by a dysregulated host response to infection that leads to life-threatening organ dysfunction.The immune response in sepsis is usually divided into two stages:hyperimmunity and immunosuppression.Immunosuppression is considered as the main cause of secondary infection and increased mortality in patients.This article reviews the main mechanisms of immunosuppression in sepsis,including dysfunction of immune cells,release of immunosuppressive cytokines,excessive activation of immunomodulatory cells,increased expression of immune checkpoints,and epigenetic dysregulation that have attracted much attention in recent years.At the same time,it also summarizes the existing and some new immunotherapy strategies.It includes immunostimulatory cytokines(such as GM-CSF,IL-7,IL-15),immune checkpoint inhibitors(such as PD-1/PD-L1 antibody,CTLA-4 antibody,TIM-3 antibody)and emerging immunotherapy methods(such as mesenchymal stem cells,calprotectin inhibitors,triggering receptor expressed on myeloid cells 1 inhibitors).This article focuses on epigenetic regulation mechanisms and emerging immunotherapies such as mesenchymal stem cells,aiming to provide theoretical support for individualized precision immunotherapy in patients with sepsis.
