Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer
10.12259/j.issn.2095-610X.S20250418
- VernacularTitle:营养干预对局部晚期胰腺癌患者生活质量和生存预后的影响
- Author:
Shijun SHEN
1
;
Yamei YIN
;
Li SONG
;
Chunming XIANG
;
Heng LI
Author Information
1. 临沧市人民医院肝胆胰微创外科,云南 临沧 677099
- Keywords:
Pancreatic cancer;
Nutritional intervention;
Locally advanced;
Quality of life
- From:
Journal of Kunming Medical University
2025;46(4):136-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of nutritional risk-based intervention on the quality of life and survival prognosis of patients with the locally advanced pancreatic cancer and undergoing the chemotherapy.Methods A total of 118 patients with the pancreatic cancer and admitted to the Department of Hepatobiliary and Minimally Invasive Surgery,Lincang People's Hospital from April 2021 to April 2024 were selected and randomly divided into the nutritional intervention group and the control group,with 59 patients in each group.All patients received the palliative chemotherapy,and the control group received the routine dietary guidance,while the intervention group received the nutritional intervention based on the nutritional risk score.The nutritional status,quality of life score,and survival prognosis of the two groups were compared.Results The NRS2002 score of the intervention group and the control group gradually increased from the first to the sixth chemotherapy,and the NRS2002 score of the intervention group was lower than that of the control group at the 4th,5th,and 6th chemotherapy(P<0.05).The incidence of malnutrition in the intervention group was lower than that of the control group at the 1st,2nd,and 3rd chemotherapy(11.9%,30.9%,and 32.2%,respectively),but there was no significant difference(P>0.05);The incidence of malnutrition in the intervention group was significantly lower than that of the control group at the 4th,5th,and 6th chemotherapy(32.2%,45.8%,and 52.5%,respectively),while the incidence of malnutrition in the control group was 59.3%,69.5%,and 88.5%,respectively(P<0.05);The quality of life score of the intervention group in all dimensions was significantly higher than that of the control group after the treatment(P<0.05).After the nutritional intervention,the median OS time and median PFS time of the patients were significantly improved(P<0.05).Conclusion Nutritional intervention can reduce the nutritional risk during the chemotherapy for locally advanced pancreatic cancer patients and improve their quality of life.
