Correlation of EGFR Gene Polymorphisms with Non-small Cell Lung Cancer in Yunnan Han Population
10.12259/j.issn.2095-610X.S20250413
- VernacularTitle:EGFR基因多态性与云南汉族人群非小细胞肺癌的关联性
- Author:
Yingfu LI
1
;
Ni GUO
;
Zhengguang LUO
;
Anhao XING
;
Taifu LI
;
Qianli MA
Author Information
1. 昆明医科大学第一附属医院呼吸与危重症三科,云南 昆明 650032
- Keywords:
Non-small cell lung cancer;
EGFR;
Single nucleotide polymorphism;
Correlation
- From:
Journal of Kunming Medical University
2025;46(4):99-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the epidermal growth factor receptor(EGFR)gene polymorphisms and non-small cell lung cancer(NSCLC)in Yunnan Han population.Methods A total of 407 NSCLC patients and 526 healthy controls were included.Five SNPs(rs1050171,rs2072454,rs2227983,rs1140475 and rs2293347)in EGFR were genotyped using TaqMan assay.The association between SNPs and NSCLC,as well as pathological types,were analyzed.Results In dominant mode,rs2072454 C/T-T/T may be a risk factor for NSCLC(P=0.004;OR=1.50,95%CI 1.14～1.96).There was a significant difference in genotype frequency between the SCC group and the control group(P=0.007),but no difference in allele frequency after Bonferroni correction(P>0.01);In the dominant mode,C/T-T/T at this locus relative to C/C was a risk for AC(P=0.002;OR=1.86,95%CI 1.24～2.80).rs1050171 A/A had a significantly higher risk of SCC in recessive mode(P=0.006,OR=2.66,95%CI 1.33～5.33).In dominant mode,rs2227983 A/G-G/G/G was a risk factor for the development of SCC relative to A/A(P=0.007;OR=1.83,95%CI 1.15～2.89).Conclusion The SNPs rs2072454,rs1050171 and rs2227983 in EGFR gene may be associated with the risk of NSCLC development as well as the type of pathology in Yunnan Han population.
