Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis
10.12259/j.issn.2095-610X.S20250409
- VernacularTitle:康复新液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎安全性和有效性的Meta分析
- Author:
Hao FAN
1
;
Xuejiao WU
;
Zhenyu CHENG
;
Xiubai TANG
;
Xing LIU
;
Hui HUANG
Author Information
1. 云南省滇东北中心医院药学部,云南 昭通 657099
- Keywords:
Kangfuxin;
Adenosine monophosphate;
Herpes stomatitis;
Meta-analysis
- From:
Journal of Kunming Medical University
2025;46(4):67-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the safety and efficacy of Kangfuxin liquid combined with adenosine monophosphate in the treatment of paediatric herpetic stomatitis.Methods Randomised controlled trials(RCTs)of Kangfuxin liquid combined with adenosine monophosphate for the treatment of paediatric herpetic stomatitis were searched in various databases,and Meta-analysis was performed using RevMan 5.4 software.Results A total of 12 RCTs with a sample size of 1,094 cases were included.Meta-analysis showed that the combination of Kangfuxin liquid with adenosine monophosphate significantly increased[RR=1.21,95%CI(1.16,1.28),P<0.000 01]the overall clinical efficacy rate of paediatric herpetic stomatitis.Compared with the conventional antiviral treatment group with adenosine monophosphate,the incidence of adverse events was lower in the Kangfuxin liquid group[RR=0.26,95%CI(0.14,0.51),P<0.000 01].In addition,the Kangfuxin liquid group could effectively shorten the time for herpes disappearance(skin lesion healing),pain disappearance,fever reduction,salivation disappearance and recovery of diet(P<0.05),and had advantages in promoting the recovery of lymphocytes(CD3+,CD4+,CD8+,and CD4+/CD8+),serological levels(CRP,TNF-α,WBC,IL-10,VEGF,EGF,and IL-6)(P<0.05).Conclusion Kangfuxin liquid combined with adenosine monophosphate has the better efficacy and safety in the treatment of paediatric herpetic stomatitis,and has advantages in shortening the symptomatic recovery time and improving the indicators of lymphocyte and serological levels in paediatric herpetic stomatitis.
