Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy
10.12259/j.issn.2095-610X.S20250401
- VernacularTitle:青蒿素及其衍生物在癌症治疗中作用机制的研究进展
- Author:
Weixing ZENG
1
;
Yongwen HE
Author Information
1. 昆明医科大学附属口腔医院口腔颌面外科,云南 昆明 650032
- Keywords:
Artemisinin;
Artemisinin derivatives;
Anticancer;
Mechanisms of action
- From:
Journal of Kunming Medical University
2025;46(4):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Due to their unique peroxide bridge structure,artemisinin and its derivatives have demonstrated the remarkable efficacy in treating severe malaria and exhibited the potent anticancer properties.These compounds interfere with the cancer cell growth through the multiple mechanisms,including the inhibition of cell proliferation,induction of various forms of cell death,cell cycle arrest,suppression of angiogenesis and modulation of the tumor microenvironment.Clinical trials have confirmed the significant anticancer activity of artemisinin-based compounds.This paper summarizes the recent advances and findings regarding the mechanisms of action of artemisinin and its derivatives as the potential anticancer agents,providing the valuable insights for future researches on the anticancer mechanisms of these compounds.
