Diagnostic Value of Adenosine Stress-resting Gated Myocardial Perfusion Imaging in the Diagnosis of Three-vessel Coronary Heart Disease
10.12259/j.issn.2095-610X.S20250319
- VernacularTitle:腺苷负荷-静息门控心肌灌注显像对冠心病三支病变患者的诊断价值
- Author:
Liju HONG
1
;
Feipeng WU
;
Qiyan WU
;
Xiandong ZHENG
;
Rui YANG
;
Dandan CHEN
;
Youjun ZHOU
Author Information
1. 昆明医科大学附属延安医院核医学科,云南 昆明 650051
- Keywords:
Adenosine;
Stress-gated myocardial perfusion imaging;
Coronary heart disease;
Three-vessel disease
- From:
Journal of Kunming Medical University
2025;46(3):124-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of adenosine load-resting gated myocardial perfusion imaging for three-vessel disease in coronary artery disease(CAD)patients using coronary angiography as the gold standard.Methods A retrospective study was conducted,including 318 patients diagnosed with CAD who underwent coronary angiography at Yanan Hospital Affiliated to Kunming Medical University from January 2021 to December 2022.Based on the results of coronary angiography,the 318 CAD patients were divided into a three-vessel disease group(n=166)and a non-three-vessel disease group(single and double vessel disease group,n=152).All the subjects underwent adenosine stress-resting GMPI within two weeks.Adenosine stress-resting GMPI myocardial perfusion parameters(SSS,SRS,SDS),cardiac function parameters(LVEF,LVEDV,LVSV)and left ventricular mechanical contraction synchronization parameters(PSD,PHB)were collected.The diagnostic value of adenosine stress-resting gated myocardial perfusion imaging for three-vessel disease in CAD was explored.Results Among the perfusion parameters,SSS had the highest AUC of 0.781,while sLVEF had the highest AUC of 0.748 among cardiac function parameters,and sPHB had the highest AUC of 0.724 among synchrony parameters.The AUCs of combined parameters were all higher than those of perfusion parameters,cardiac function parameters,and synchrony parameters(P＜0.05).The changes in Δ LVESV and Δ LVEF between the three-vessel disease group and the non-three vessel disease group showed statistical significance(P＜0.05).Conclusion The perfusion,cardiac function and synchronization parameters of adenosine stress-resting gated myocardial perfusion imaging have high diagnostic value for three-vessel coronary heart disease,and the combined detection of the three parameters provides even greater diagnostic value for three-vessel coronary heart disease.
