The Effectiveness of Liraglutide Combined with Metformin in Improving Glycolipid Metabolism and Hormonal Levels in Polycystic Ovary Syndrome:A Meta-Analysis
10.12259/j.issn.2095-610X.S20250313
- VernacularTitle:利拉鲁肽联合二甲双胍对改善多囊卵巢综合征糖脂代谢及性激素水平有效性的荟萃分析
- Author:
Xiaohui GU
1
;
Fenrong LV
;
Ju SUN
;
Yaping PENG
;
Dandan WAN
Author Information
1. 曲靖市第二人民医院全科医学科(老年病科),云南曲靖 655099
- Keywords:
Liraglutide;
Metformin;
Polycystic ovary syndrome;
Glycolipid metabolism
- From:
Journal of Kunming Medical University
2025;46(3):79-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effects of liraglutide combined with metformin on glucose and lipid metabolism,sex hormones,reproductive function,and gastrointestinal reactions in patients with polycystic ovary syndrome(PCOS).Methods We searched databases such as PubMed,WanFang Medical Network,WanFang Database,China National Knowledge Infrastructure(CNKI),and VIP Journals to collect randomized controlled trials published from January 2011 to August 2022 on the treatment of polycystic ovary syndrome with liraglutide combined with metformin,using Revman 5.4 for the meta-analysis.Results A total of 16 case-control studies were included,involving 1436 patients.Compared to metformin alone,the combination of liraglutide and metformin significantly lowered fasting blood sugar,postprandial blood glucoseafter 2 hours,HbA1c,HOMA-IR,FINS,BMI,as well as LH,FSH,and total testosterone in patients with PCOS.It improved lipid levels,helped establish menstrual cycles,and increased the normal ovulation rate and natural conception rate in these patients.However,there was a significantly higher incidence of gastrointestinal reactions in the liraglutide plus metformin group,and the difference was statistically significant(P＜0.05).Conclusion The combination of liraglutide and metformin can improve glucose and lipid metabolism in patients with polycystic ovary syndrome(PC OS),reduce levels of LH,FSH,and total testosterone,help establish regular menstrual cycles,and increase ovulation and pregnancy rates,but it significantly increases gastrointestinal side effects.
