Single-cell RNA Sequencing:A New Perspective in the Study of Chronic Obstructive Pulmonary Disease
10.12259/j.issn.2095-610X.S20250301
- VernacularTitle:单细胞RNA测序:慢性阻塞性肺疾病研究的新视角
- Author:
Menghuan LI
1
;
Li AI
;
Yongxia LI
Author Information
1. 昆明医科大学第二附属医院呼吸与危重症医学科,云南 昆明 650101
- Keywords:
Single-cell RNA sequencing;
Chronic obstructive pulmonary disease;
Cellular heterogeneity;
Pathogenesis;
Clinical application
- From:
Journal of Kunming Medical University
2025;46(3):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease(COPD)is a polygenic disease influenced by the interaction of genetic and environmental factors,characterized by persistent airflow limitation and chronic respiratory symptoms.Traditional gene sequencing methods have revealed the genetic basis of COPD but are limited by the average data of cell populations,making it difficult to fully display the complexity of the disease.Single-cell RNA sequencing technology provides a new perspective,allowing researchers to analyze gene expression at the individual cell level,revealing cellular heterogeneity,which is of great significance for understanding the pathological process of COPD,discovering biomarkers,and personalized medicine.This article reviews the principles of single-cell sequencing technology and its application in COPD research.
