Research Progress on Targeted Therapy and Resistance Mechanisms of Malignant Melanoma
10.12259/j.issn.2095-610X.S20250222
- VernacularTitle:恶性黑色素瘤靶向治疗及其耐药机制研究进展
- Author:
Yifan LIU
1
;
Xing LUO
;
Tianci SONG
;
Zhihui YANG
Author Information
1. 西南医科大学基础医学院,四川 泸州 646000;重大疾病精准病理诊断泸州市重点实验室,四川 泸州 646000
- Keywords:
Malignant melanoma;
Targeted therapy;
Drug resistance mechanisms
- From:
Journal of Kunming Medical University
2025;46(2):158-163
- CountryChina
- Language:Chinese
-
Abstract:
Malignant melanoma is an extremely aggressive tumor that can be surgically treated in its early stage.In advanced stages,the invasive and proliferative capabilities of melanoma cells continue to increase,and traditional treatment methods such as radiotherapy,chemotherapy,and immunotherapy have limited efficacy,resulting in poor patient prognosis.Due to the presence of mutations in multiple molecular pathways in malignant melanoma,targeted therapy is now regarded as a more viable treatment option for patients with advanced malignant melanoma,with most patients benefiting from it.However,the development of drug resistance to targeted therapy has always been a serious challenge,as the emergence of resistance limits the efficacy.Therefore,it is necessary to explore the mechanism and drug resistance of targeted therapy of malignant melanoma.
