The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia
10.12259/j.issn.2095-610X.S20250207
- VernacularTitle:miR-146a基因多态性与宫颈上皮内瘤变的相关性
- Author:
Yuhan SHI
1
;
Jianghong CHAI
;
Jinmei XU
;
Mu LIN
;
Yufeng YAO
;
Fengquan HE
;
Zhiling YAN
Author Information
1. 中国医学科学院 & 北京协和医学院医学生物学研究所,云南 昆明 650118
- Keywords:
MicroRNAs;
Cervical intraepithelial neoplasia;
Single nucleotide polymorphisms
- From:
Journal of Kunming Medical University
2025;46(2):44-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between single nucleotide polymorphisms(SNP)rs57095329 and rs6864584 of miR-146a gene and cervical intraepithelial neoplasia(CIN).Methods A total of 96 patients diagnosed with CIN were randomly collected as the CIN group,and 225 healthy individuals examined during the same period were selected as the control group using SPSS software.Genotyping of the above SNP loci was performed using the TaqMan probe method,and their correlation with CIN was analyzed.Results The allele and genotype distribution of rs57095329 showed a statistically significant differences compared to the control group,with the frequency of the allele A in the CIN group significantly lower than that in the control group(P<0.001;OR=0.48,95%CI:0.32～0.70).In the dominant model,individuals carrying the G allele(A/G-G/G)had a significantly increased risk of CIN(P<0.001;OR=2.67,95%CI:1.64～4.37).In contrast,no correlation was found between the rs6864584 and the risk of CIN.Conclusion The A allele of the miR-146a gene at the rs57095329 locus may be a protective factor for CIN.
