Research Progress on CCL3 in the Pathogenesis of AIDS
10.12259/j.issn.2095-610X.S20250201
- VernacularTitle:CCL3在艾滋病发病机制中的研究进展
- Author:
Yuanju LIU
1
;
Xiaolan LI
;
Jie LIU
;
Yinde XU
;
Yun ZHU
Author Information
1. 昆明医科大学第二附属医院皮肤性病科,云南 昆明 650101
- Keywords:
Chemokine;
Chemokine(C-C motif)ligand 3;
Acquired immune deficieny syndrome
- From:
Journal of Kunming Medical University
2025;46(2):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Acquired immune deficiency syndrome(AIDS)is a systemic disease caused by the Human Immunodeficiency Virus(HIV).Chemokine(C-C motif)ligand 3(CCL3),as a vital member of the chemokine family,plays an indispensable role in the pathogenesis of AIDS.In the context of AIDS,CCL3 exerts significant antiviral and immunomodulatory effects by preventing HIV entry into target cells,activating immune cells to enhance antiviral capabilities,and modulating inflammatory responses,thereby influencing disease progression.Numerous studies have demonstrated that CCL3 gene copy number,specific T-cell responses,CCL3 polymorphisms,and the signaling pathways it participates in all influence the development of HIV and viral load.This article comprehensively reviews the multifaceted roles of CCL3 in AIDS,including its ability to block HIV-1 entry into immune cells,inducing the expression of antiviral proteins to inhibit viral replication,as well as the influence of its polymorphisms and alleles on HIV infection and disease progression,aiming to provide novel theoretical support for AIDS prevention and treatment strategies.
