Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value
10.12259/j.issn.2095-610X.S20250118
- VernacularTitle:儿童肥胖症中IGF-1和IGFBP-3的水平及诊断价值
- Author:
Lisi LUO
1
;
Qingxiong YANG
;
Yan WANG
;
Sixiang LIU
;
Zhen XU
;
Yu LING
Author Information
1. 昆明市儿童医院儿保科,云南 昆明 650034
- Keywords:
Childhood obesity;
Diagnosis;
IGF-1;
IGFBP-3
- From:
Journal of Kunming Medical University
2025;46(1):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value.Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children's Hospital from December 2023 and March 2024,and were divided into a control group(healthy children;n=115)and a study group(obese children;n=86).Serum levels of IGF-1 and IGFBP-3 in both groups were measured by using ELISA.Clinical data from both groups were analyzed to assess the correlation between IGF-1 and IGFBP-3 and clinical information,as well as their diagnostic value in childhood obesity.Results Compared to the control group,the study group exhibited a significant increase in weight and BMI(P<0.001)while IGF-1 and IGFBP-3 levels were significantly lower(P<0.05).IGF-1 levels exhibited a negative correlation with total cholesterol,triglycerides,apolipoprotein B,and insulin resistance index(P<0.05),and a positive correlation with apolipoprotein A and fasting insulin(P<0.05);IGFBP-3 displayed the opposite pattern(P<0.05).ROC diagnostic curves indicated that the area under the curve for IGF-1 and IGFBP-3 was 0.598 and 0.665,respectively.Conclusion IGF-1 and IGFBP-3 are expressed at low levels in childhood obesity and are associated with obesity indicators,demonstrating certain diagnostic value.
