Signal Mining and Analysis of Adverse Events of Azithromycin Based FAERS Database
10.12259/j.issn.2095-610X.S20250103
- VernacularTitle:基于FAERS数据库的阿奇霉素不良事件的信号挖掘与分析
- Author:
Qinglan PENG
1
;
Jialu LUO
;
Jiayi YU
;
Kaixin WANG
;
Fang WU
;
Chuanzhi XU
Author Information
1. 三峡大学健康医学院,湖北 宜昌 443000;三峡大学皮肤性病研究所,湖北 宜昌 443000
- Keywords:
Azithromycin;
Adverse drug events;
FDA adverse event reporting system;
Data mining and analysis data mining
- From:
Journal of Kunming Medical University
2025;46(1):16-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and analyze adverse drug events(ADE)signals of azithromycin,identify common adverse events and suspected adverse reactions that occur easily in the real clinical application of azithromycin.Methods The adverse drug event reports related to azithromycin recorded in the US FDA Adverse Event Reporting System database from October 1,2003,to October 1,2023,were mined using the OpenVigil 2.1 drug surveillance platform.Signal detection and analysis were carried out using the reporting odds ratio(ROR)and Bayesian confidence propagation neural network method(BCPNN).Results A total of 5498 ADE signals were identified,with a total of 112485 reports.Eventually,31,041 azithromycin-associated adverse event reports were extracted,involving 898 positive signals,27 system organ classes,mainly concentrated in respiratory system diseases,infections,gastrointestinal system diseases,and others.Additionally,some adverse reactions possibly caused by azithromycin were discovered,such as asthma,wheezing,and potential reactions like incomplete abortion.Conclusion When using azithromycin,besides paying attention to the adverse reactions listed in the drug instructions,we should also pay attention to some adverse reactions that have not been timely recorded or updated,in order to prevent the medication safety risks caused by outdated instructions,provide reasonable medication advice,and ensure the medication safety of patients.
