The Role of Macrophage Polarization in Thrombotic Diseases
10.12259/j.issn.2095-610X.S20250101
- VernacularTitle:巨噬细胞极化在部分血栓性疾病中的作用
- Author:
Haopeng SHENTU
1
;
Jing YANG
;
Weiqing GE
;
Tao ZHOU
;
En SONG
Author Information
1. 昆明医科大学第一附属医院运动医学科,云南 昆明 650032
- Keywords:
Thrombotic diseases;
Deep vein thrombosis;
Macrophages;
Macrophage polarization
- From:
Journal of Kunming Medical University
2025;46(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Thrombotic diseases refer to a group of conditions characterized by abnormal blood coagulation within blood vessels,leading to the formation of blood clots and a series of clinical symptoms.This includes diseases such as deep vein thrombosis in the lower extremities,stroke,atherosclerosis,and diabetes.Thrombosis is a complex,progressive process that can be broadly summarized as the exposure of vascular endothelial damage,activation of the intrinsic coagulation system,platelet adhesion and aggregation,fibrin network formation,blood cell stasis.Macrophages play an important role in this process.They are involved in local inflammatory responses,regulating both the formation and resolution of thrombi.Macrophage polarization is a hot research topic in recent years,which mainly refers to the morphological and functional changes of macrophages in response different environmental stimuli.Macrophage polarization can be classified into classical(M1)and alternative(M2)types,as well as several specialized polarization states.The transition of macrophage polarization states plays an important role in immune responses,pathogen infections,tumor immunity,and autoimmune processes.This review discusses the regulatory relationship of macrophage polarization in thrombotic diseases,providing new directions for the treatment of these conditions.
